Human Recombinant Leptin

Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses. Leptin can both promote osteogenesis via osteoblast receptors and inhibit it thro μgh its actions on the hypothalamus. It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase.