Human Recombinant LIF, ACF

Leukemia inhibitory factor. LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype. Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment. Human LIF can be used for the maintenance of mouse embryonic stem cells, however mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive. LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes. This product is animal component-free.