Human T cell acute lymphocytic leukemia Protein 1(TAL1) ELISA Kit (RMEK-0152942)
Cat. No.: RMEK-0152942
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Human |
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| Assay Time | 1.5 h |
Target Information
| Target Symbol | TAL1 |
|---|---|
| UniProt ID | P17542 |
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). |
| Cellular Localization | Nucleus. |
| Domain | The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1. |
| Post-transcriptional Modifications | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity). Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). |
| Involvement in Disease | A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1; 14)(p32; q11) with T-cell receptor alpha chain (TCRA) genes. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
