Human/Mouse PIM1 Antibody Pair - BSA and Azide free (RMAB-0252082)
Cat. No.: RMAB-0252082
Category: Antibody Pair
INQUIRY
10 x 96 tests
Human/Mouse PIM1 Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to quantify Human/Mouse PIM1 in sandwich ELISAs and many other pair-based applications._x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Mouse, Human |
| Range | 78 pg/mL - 5000 pg/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Mouse, Human |
Target Information
| Target Symbol | PIM1 |
|---|---|
| Target Name | Serine/threonine-protein kinase pim-1 |
| UniProt ID | P11309 |
| Cellular Localization | Cytoplasm. Nucleus and Cell membrane. |
| Function | May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis. |
| Post-translational Modifications | Autophosphorylated on both serine/threonine and tyrosine residues. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
|---|
For research use only. Not for clinical use.
