Idealized network 3D inflammation model assay Kit (RMCC-00540003)
Cat. No.: RMCC-00540003
Category: Other Kits
INQUIRY
Case of 1 ea
Product Features
| Components | 10 - IMN2 8 μm gap, 3 μm height pillar barrier chips, 100 ft Tygon Tubing, 25 pack Slide Clamps, 50 pack 1 mL Syringe with Luer-Lok Tip, 50 pack 24 Gauge Needle x 0.5 in long |
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| Description | The 3D Inflammation Model from has been developed to study the entire inflammation pathway in a realistic and dynamic environment. By recreating a histological slice of co-cultured tissue and/or tμmor cells with a lμmen of endothelial cells, the platform delivers a physiologically realistic model including flow and shear in a platform and enables real-time tracking of rolling, adhesion and migration processes. This model has been successfully validated against in vivo studies showing excellent correlation with rolling velocities, adhesion patterns and migratory processes. |
| Key Features | This innovative design overcomes the current limitations inherent in flow chambers or Transwell chamber based assays. Current flow chamber designs are oversimplified, lack the scale and geometry of the microenvironment and cannot model transmigration. Similarly, Transwell chambers do not account for fluid shear and size/topology observed in vivo, the end point measurements of migration are not reproducible and do not provide real-time visualization. This proprietary chip designs range from complex in vivo derived microvascular networks (obtained from digitized images) to produce realistic cellular makeup and vascular morphology resulting in varying shear and flow conditions, to simplified idealized networks designed to reproduce the cellular makeup and constant shear and flow conditions. |
Storage & Shipping
| Storage | Room temperature |
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| Shipping | Shipped on gel packs. |
For research use only. Not for clinical use.
