Jervine, Hedgehog (Hh) signaling inhibitor (RMML-00120953)
Cat. No.: RMML-00120953
Category: Inhibitors & Activators
INQUIRY
5 mg
1 mg
Smoothened inhibitor
Product Features
| Source | Veratrum nigrum L. |
|---|---|
| Purity | > 98% |
| Key Features | Smoothened inhibitor; CAS Number: 469-59-0; Purity: > 98%; Soluble in DMSO to 10 mM and in ethanol to 10 mM; Form / State: Solid; Source: Veratrum nigrum L. |
Compound Information
| Target Pathways | Hh |
|---|---|
| Biological Description | Smoothened inhibitor (IC50 = 500-700 nM). Steroidal alkaloid. Prevents hedgehog signaling and therefore Gli1 transcription. |
| Alternative Names | 11-Ketocyclopamine |
| CAS Number | 469-59-0 |
| Chemical Name | (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one |
| Molecular Formula | C27H39NO3 |
| Molecular Weight | 425.61 Da |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 10 mM and in ethanol to 10 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
