LGK974 (RMML-00120769)
Cat. No.: RMML-00120769
Category: Inhibitors & Activators
INQUIRY
5 mg
1 mg
Potent Porcupine (porcn) inhibitor
Product Features
| Purity | ≥ 98% |
|---|---|
| Key Features | Potent Porcupine (porcn) inhibitor; CAS Number: 1243244-14-5; Purity: ≥ 98%; DMSO (~35 mg/mL); Form / State: Solid |
Compound Information
| Biological Description | LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC50 = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974. |
|---|---|
| Alternative Names | LGK-974, LGK974, WNT-974, WNT974 |
| CAS Number | 1243244-14-5 |
| Chemical Name | 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide |
| SMILES | CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4 |
| Molecular Formula | C23H20N6O |
| Molecular Weight | 396.44 Da |
| PubChem Identifier | 46926973 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
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| Solubility | DMSO (~35 mg/mL) |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Store in the dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
For research use only. Not for clinical use.
