Mouse Fas Ligand Antibody Pair - BSA and Azide free (FasL) (RMAB-0252268)
Cat. No.: RMAB-0252268
Category: Antibody Pair
INQUIRY
10 x 96 tests
The Antibody Pair can be used to quantify Mouse Fas Ligand (FasL). BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/mL as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results._x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Mouse |
| Range | 18.75 pg/mL - 1200 pg/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Mouse |
Target Information
| Target Symbol | FASLG |
|---|---|
| Target Name | Tumor necrosis factor ligand superfamily member 6 |
| UniProt ID | P48023 |
| Cellular Localization | Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface. |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. |
| Involvement in Disease | Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B); also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. |
| Post-translational Modifications | N-glycosylated. The soluble form derives from the membrane form by proteolytic processing. |
| Sequence Similarities | Belongs to the tumor necrosis factor family. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
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For research use only. Not for clinical use.
