Mouse Wingless Type MMTV integration site family, member 4 ELISA Kit (RMEK-0154032)
Cat. No.: RMEK-0154032
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Mouse |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | WNT4 |
|---|---|
| UniProt ID | P56705 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. |
| Post-transcriptional Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
| Involvement in Disease | 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL): A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. The disease is caused by variants affecting the gene represented in this entry. Mullerian aplasia and hyperandrogenism (MULLAPL): A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
