PD 184352 (CI-1040), ATP non-competitive MEK1/2 inhibitor (RMML-00120784)
Cat. No.: RMML-00120784
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Potent, highly selective ATP non-competitive MEK1/2 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Potent, highly selective ATP non-competitive MEK1/2 inhibitor; CAS Number: 212631-79-3; Purity: > 99%; Soluble in DMSO 100 mM and in ethanol to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | MEK1/2 |
|---|---|
| Biological Description | Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Prevents ERK phosphorylation (IC50 = 100-500 nM) and subsequent signalling. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active. |
| Alternative Names | PD184352 |
| CAS Number | 212631-79-3 |
| Chemical Name | 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy-3,4-difluorobenzamide |
| SMILES | c1cc(c(cc1I)Cl)Nc2c(ccc(c2F)F)C(=O)NOCC3CC3 |
| Molecular Formula | C17H14ClF2IN2O2 |
| Molecular Weight | 478.66 Da |
| PubChem Identifier | 6918454 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO 100 mM and in ethanol to 25 mM |
| Storage & Shipping | Store at 4°C. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
