PP1

PP1 is a reversible inhibitor of the SRC family of tyrosine kinases. It inhibits LCK, FYN, HCK and SRC with IC₅₀ values of 5, 6, 20 and 170 nM, respectively. It is relatively selective for SRC family kinases versus other kinases, inhibiting epidermal growth factor receptor. PP1 also blocks TGF-β-mediated cellular responses by directly inhibiting type I TGF-β receptors. Enables reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells in the absence of reprogramming factor SOX2. Blocks TGF-β-mediated migration of primary non-small cell lung carcinoma cells and pancreatic ductal adenocarcinoma cell lines. Induces apoptosis in non-small cell lung cancer cell lines.