R428 (BGB324), AXL inhibitor (RMML-00120735)
Cat. No.: RMML-00120735
Category: Inhibitors & Activators
INQUIRY
5 mg
25 mg
Potent and selective AXL kinase inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent and selective AXL kinase inhibitor; CAS Number: 1037624-75-1; Purity: > 98%; Soluble in DMSO to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | AXL |
|---|---|
| Biological Description | Potent and selective inhibitor of AXL kinase (IC50 = 14 nM). Overcomes chemotherapy resistance to various agents in multiple cancer models. Suppresses myeloid cell activation and function. AXL inhibition combined with PD-1 blockade shows potent synergistic anti-tumor effects. Greater than 100-fold selective for AXL versus ABL. Selective (50-100-fold) versus Mer and Tyro3 in cell-based assays. Highly selective for AXL versus InsR, EGFR, HER2, and PDGFRbeta in cell-free assays. |
| CAS Number | 1037624-75-1 |
| Chemical Name | 1-(3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine |
| SMILES | c1ccc-2c(c1)CCCc3c2nnc(c3)n4c(nc(n4)Nc5ccc6c(c5)CC[C@H](CC6)N7CCCC7)N |
| Molecular Formula | C30H34N8 |
| Molecular Weight | 506.64 Da |
| PubChem Identifier | 46215462 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 25 mM |
| Storage & Shipping | Shipped at room temperature. Store at -20°C. Store under desiccating conditions. |
For research use only. Not for clinical use.
