Recombinant cynomolgus Monkey CD86 Protein (Active) (RMPP-00230026)
Cat. No.: RMPP-00230026
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
100 μg
Customer Size
Product Features
| Nature | Synthetic |
|---|---|
| Animal Free | No |
| Form | Lyophilized |
| Applications | Blocking |
| Application Note | Blocking - Blocking peptide for Anti-c-Myc antibody - ChIP Grade |
| Key Features | Suitable for: Blocking |
Protein Information
| UniProt ID | P01106 |
|---|---|
| Sequence Similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
| Cellular Localization | Nucleus > nucleoplasm. Nucleus > nucleolus. |
| Function | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CACTG-3'. Seems to activate the transcription of growth-related genes. |
| Involvement in Disease | Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.Defects in MYC are a cause of Burkitt lymphoma (BL). A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. |
| Post-translational Modifications | Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at -20°C. Information available upon request. |
|---|
For research use only. Not for clinical use.
