Recombinant Human BAFF-R Protein (Fc Chimera) (RMPP-00230494)
Cat. No.: RMPP-00230494
Category: Recombinant Protein
Research Area: Neuroscience
INQUIRY
25 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | > 95% SDS-PAGE. >98% by SDS-PAGE and HPLC analysis. Endotoxin level is <0. 1 ng per µg of PTHrP. Sterile filtered. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | His tag N-Terminus |
| Form | Lyophilized |
| Applications | HPLC; SDS-PAGE |
| Key Features | Expression system: E.coli; Purity: > 95% SDS-PAGE; Tags: His tag N-Terminus; Suitable for: HPLC, SDS-PAGE |
Protein Information
| UniProt ID | P12272 |
|---|---|
| Sequence Similarities | Belongs to the parathyroid hormone family. |
| Protein Length | Protein fragment |
| Cellular Localization | Cytoplasm. Nucleus. Secreted. |
| Tissue Specificity | Ubiquitous. Also expressed in the mammary gland. |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.Osteostatin is a potent inhibitor of osteoclastic bone resorption. |
| Involvement in Disease | Brachydactyly E2 |
| Post-translational Modifications | There are 3 principal secretory forms, called PTHrP, PTHrP, and osteostatin (PTHrP) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Constituent: PBS |
|---|
For research use only. Not for clinical use.
