Recombinant Human c-Kit (mutated D816E) Protein (Active) (RMPP-00230484)
Cat. No.: RMPP-00230484
Category: Growth Factors & Cytokines
Research Area: Signal Transduction
INQUIRY
5 μg
Customer Size
Product Features
| Source | HEK 293 cells |
|---|---|
| Purity | > 98% SDS-PAGE. > 98% HPLC analyses. |
| Nature | Recombinant |
| Endotoxin Level | < 1.000 Eu/µg |
| Animal Free | No |
| Form | Lyophilized |
| Applications | HPLC; Functional Studies; SDS-PAGE; WB |
| Key Features | Expression system: HEK 293 cells; Purity: > 98% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Suitable for: HPLC, Functional Studies, SDS-PAGE, WB |
Protein Information
| UniProt ID | P61812 |
|---|---|
| Molecular Weight | 25 kDa |
| Sequence | ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS |
| Sequence Similarities | Belongs to the TGF-beta family. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Function | TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. |
| Involvement in Disease | A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.Loeys-Dietz syndrome 4Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features. |
| Post-translational Modifications | The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Stable for 12 months at -20°C. This product is an active protein and may elicit a biological response in vivo, handle with caution. |
|---|
For research use only. Not for clinical use.
