Recombinant Human c-Kit (mutated V560G + N822K) Protein (Active) (RMPP-00230472)
Cat. No.: RMPP-00230472
Category: Recombinant Protein
Research Area: Stem Cells
INQUIRY
5 μg
Customer Size
Product Features
| Source | CHO cells |
|---|---|
| Purity | > 95% SDS-PAGE. The purity ofthis product is greater than 98% by SDS-PAGE gel and HPLC analyses. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Lyophilized |
| Applications | HPLC; Functional Studies; SDS-PAGE |
| Key Features | Expression system: CHO cells; Purity: > 95% SDS-PAGE; Active: Yes; Suitable for: HPLC, Functional Studies, SDS-PAGE |
Protein Information
| UniProt ID | Q9UBU2 |
|---|---|
| Molecular Weight | 26 kDa |
| Sequence | SQIGSSRAKL NSIKSSLGGE TPGQAANRSA GMYQGLAFGG SKKGKNLGQA YPCSSDKECE VGRYCHSPHQ GSSACMVCRR KKKRCHRDGM CCPSTRCNNG ICIPVTESIL TPHIPALDGT RHRDRNHGHY SNHDLGWQNL GRPHTKMSHI KGHEGDPCLR SSDCIEGFCC ARHFWTKICK PVLHQGEVCT KQRKKGSHGL EIFQRCDCAK GLSCKVWKDA TYSSKARLHV CQKI |
| Sequence Similarities | Belongs to the dickkopf family. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Tissue Specificity | Expressed in heart, brain, skeletal muscle and lung. |
| Domain | The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Post-translational Modifications | May be proteolytically processed by a furin-like protease. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at -20°C. This product is an active protein and may elicit a biological response in vivo, handle with caution. |
|---|
For research use only. Not for clinical use.
