Recombinant Human Casein Kinase 1 gamma 2 Protein (RMPP-00231019)
Cat. No.: RMPP-00231019
Category: Recombinant Protein
Research Area: Cell Biology
INQUIRY
10 μg
Customer Size
Product Features
| Source | Baculovirus infected Sf9 cells |
|---|---|
| Purity | > 70% Densitometry. Affinity purified. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | GST tag N-Terminus |
| Form | Liquid |
| Applications | WB; SDS-PAGE |
| Key Features | Expression system: Baculovirus infected Sf9 cells; Purity: > 70% Densitometry; Tags: GST tag N-Terminus; Suitable for: WB, SDS-PAGE |
Protein Information
| UniProt ID | Q9Y2T1 |
|---|---|
| Molecular Weight | 130 kDa including tags |
| Sequence | MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMS VSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLE REKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLK PATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYV RSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGL SSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLP HFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIRE DEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTP GCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLL GGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYY CYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESAR SSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEA CRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEP KKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGN YRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID |
| Sequence Similarities | Contains 1 DIX domain. Contains 1 RGS domain. |
| Protein Length | Full length protein |
| Cellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in brain and lymphoblast. |
| Domain | The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2. |
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Involvement in Disease | Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. |
| Post-translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A.ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. pH: 7.50Constituents: 0.31% Glutathione, 25% Glycerol (glycerin, glycerine), 0.29% Sodium chloride, 0.79% Tris HCl, 0.003% EDTA, 0.004% DTT, 0.002% PMSF |
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For research use only. Not for clinical use.
