Recombinant Human COMP/Cartilage oligomeric matrix Protein (Active) (RMPP-00230840)
Cat. No.: RMPP-00230840
Category: Recombinant Protein
Research Area: Neuroscience
INQUIRY
100 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | > 90% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | His tag N-Terminus |
| Form | Liquid |
| Applications | SDS-PAGE; MS |
| Key Features | Expression system: E.coli; Purity: > 90% SDS-PAGE; Tags: His tag N-Terminus; Suitable for: SDS-PAGE, MS |
Protein Information
| UniProt ID | P14136 |
|---|---|
| Molecular Weight | 66 kDa including tags |
| Sequence | MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFS LAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQ LRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQ KLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKI YEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQET EEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTN ESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLL NVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGH LKRNIVVKTVEMRDGEVIKDSKQEHKDVVM |
| Sequence Similarities | Belongs to the intermediate filament family. |
| Protein Length | Full length protein |
| Cellular Localization | Cytoplasm. Associated with intermediate filaments. |
| Tissue Specificity | Expressed in cells lacking fibronectin. |
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Involvement in Disease | Defects in GFAP are a cause of Alexander disease (ALEXD). Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. |
| Post-translational Modifications | Phosphorylated by PKN1. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 7.20Constituents: 50% Glycerol (glycerin, glycerine), Tris buffer |
|---|
For research use only. Not for clinical use.
