Recombinant Human FGF-19 (RMPP-00231550)
Cat. No.: RMPP-00231550
Category: Growth Factors & Cytokines
INQUIRY
5 μg
25 μg
The FGF family plays central roles during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-19, a member of the FGF family, is a high-affinity heparin-dependent ligand for FGFR4. FGF-19 is expressed during brain development and embryogenesis. Recombinant Human FGF-19 is a 21.8 kDa protein containing 195 amino acid residues.
Product Features
| Source | E.coli |
|---|---|
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Nature | Recombinant |
| Endotoxin Level | < 1 Eu/μg |
| Cross Reactivity | Chicken, Hamster, Human, Mouse |
Protein Information
| UniProt ID | O95750 |
|---|---|
| Molecular Weight | 21.8 kDa |
| Molecular Weight Information | Mass determination by ESI-TOF. Predicted MW is 21486.46 Da (+/- 10 Da by ESI-TOF). Observed MW is 21357.53 |
| Sequence Similarities | Belongs to the heparin-binding growth factors family. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Tissue Specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. |
|---|
For research use only. Not for clinical use.
