Recombinant Human NT-3 (RMPP-00231458)
Cat. No.: RMPP-00231458
Category: Neurotrophins
INQUIRY
2 μg
10 μg
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal thro μgh the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).
Product Features
| Source | E.coli |
|---|---|
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Nature | Recombinant |
| Endotoxin Level | < 1 Eu/μg |
| Cross Reactivity | Chicken, Cow, Dog, Frog, Hamster, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat |
Protein Information
| UniProt ID | P20783 |
|---|---|
| Molecular Weight | 27.2 kDa |
| Sequence | MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT |
| Sequence Similarities | Belongs to the NGF-beta family. |
| Protein Length | Protein fragment |
| Cellular Localization | Secreted. |
| Tissue Specificity | Brain and peripheral tissues. |
| Function | Seems to promote the survival of visceral and proprioceptive sensory neurons. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. |
|---|
For research use only. Not for clinical use.
