Recombinant Human Oct4 Protein (RMPP-00231001)
Cat. No.: RMPP-00231001
Category: Recombinant Protein
Research Area: Microbiology
INQUIRY
50 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | > 95% Immunogen affinity purified. Purified LRH-1 protein is greater than 95% homogeneous and contains no detectable protease, DNase, and RNase activity. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Liquid |
| Applications | WB; Gel Supershift Assays; EMSA |
| Key Features | Expression system: E.coli; Purity: > 95% Immunogen affinity purified; Suitable for: WB, GSA |
Protein Information
| UniProt ID | O00482 |
|---|---|
| Sequence Similarities | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. |
| Tissue Specificity | Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. |
| Function | Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. |
Storage & Shipping
| Shipping and Storage | Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. pH: 7.9Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol (glycerin, glycerine) |
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For research use only. Not for clinical use.
