Recombinant Human Osteocalcin Protein (RMPP-00230276)
Cat. No.: RMPP-00230276
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
2 μg
Customer Size
Product Features
| Source | Baculovirus infected Sf9 cells |
|---|---|
| Purity | > 85% Densitometry. Densitometry was followed by the affinity column that resulted in >95% purity. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | GST tag N-Terminus |
| Form | Liquid |
| Applications | Functional Studies; SDS-PAGE |
| Key Features | Expression system: Baculovirus infected Sf9 cells; Purity: > 85% Densitometry; Active: Yes; Tags: GST tag N-Terminus; Suitable for: Functional Studies, SDS-PAGE |
Protein Information
| UniProt ID | Q9UBN7 |
|---|---|
| Molecular Weight Information | SDS-PAGE molecular weight: ~150kDa |
| Sequence | MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEV KKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCL WDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYI DLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLG AEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIV DWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG DPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLH TLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNM EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHH PEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRA TEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDV HHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFT VNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLG GCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKL VTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQ TTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAME GATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLI GSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTD QAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQ VYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN IAHQNKFGEDMPHPH |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 2 subfamily. Contains 1 UBP-type zinc finger. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. Cytoplasm. It is mainly cytoplasmic, where it is associated with microtubules. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. |
| Post-translational Modifications | Ubiquitinated. Its polyubiquitination however does not lead to its degradation.Sumoylated in vitro. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. pH: 7.50Constituents: 0.79% Tris HCl, 0.87% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.004% DTT, 0.002% PMSF, 25% Glycerol This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
