Recombinant Human PIM1 Protein (RMPP-00230032)
Cat. No.: RMPP-00230032
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
10 μg
5 μg
Product Features
| Purity | > 70% HPLC. 70 - 90% by HPLC |
|---|---|
| Nature | Synthetic |
| Animal Free | No |
| Form | Liquid |
| Applications | Blocking |
| Application Note | Blocking - Blocking peptide for Anti-Oct4 antibody |
| Key Features | Purity: > 70% HPLC; Suitable for: Blocking |
Protein Information
| UniProt ID | Q01860 |
|---|---|
| Sequence Similarities | Belongs to the POU transcription factor family. Class-5 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain. |
| Cellular Localization | Nucleus. Expressed in a diffuse and slightly punctuate pattern. |
| Tissue Specificity | Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. |
| Developmental Stage | Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation. |
| Domain | The POU-specific domain mediates interaction with PKM2. |
| Function | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Post-translational Modifications | Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Information available upon request. |
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For research use only. Not for clinical use.
