Recombinant Human TGF-α (RMPP-00231536)
Cat. No.: RMPP-00231536
Category: Growth Factors & Cytokines
INQUIRY
20 μg
100 μg
TGF-α is an EGF-related polypeptide growth factor that signals thro μgh the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Product Features
| Source | E.coli |
|---|---|
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Nature | Recombinant |
| Endotoxin Level | < 1 Eu/μg |
| Cross Reactivity | Chicken, Horse, Human, Mouse, Rat |
Protein Information
| UniProt ID | P01135 |
|---|---|
| Molecular Weight | 5.5 kDa |
| Sequence Similarities | Contains 1 EGF-like domain. |
| Protein Length | Full length protein |
| Cellular Localization | Cell membrane and Secreted > extracellular space. |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. |
| Function | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. |
|---|
For research use only. Not for clinical use.
