Recombinant rhesus Monkey PCSK9 Protein (Active) (RMPP-00230278)
Cat. No.: RMPP-00230278
Category: Recombinant Protein
Research Area: Epigenetics and Nuclear Signaling
INQUIRY
50 μg
Customer Size
Product Features
| Source | Baculovirus infected Sf9 cells |
|---|---|
| Purity | > 80% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | His tag C-Terminus |
| Form | Liquid |
| Applications | Functional Studies; SDS-PAGE |
| Key Features | Expression system: Baculovirus infected Sf9 cells; Purity: > 80% SDS-PAGE; Active: Yes; Tags: His tag C-Terminus; Suitable for: Functional Studies, SDS-PAGE |
Protein Information
| UniProt ID | Q9BY41 |
|---|---|
| Molecular Weight Information | SDS-PAGE molecular weight: ~47kDa |
| Sequence | MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVV |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. |
| Tissue Specificity | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. |
| Post-translational Modifications | Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. pH: 7.00Preservative: 1.02% ImidazoleConstituents: 1.05% MOPS, 1.74% Sodium chloride, 0.002% PMSF, 0.004% DTT, 25% Glycerol This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
