Reversine

Reversine is a 2,6-disubstituted purine derivative that inhibits the human A3 adenosine receptor, nonmuscle myosin II heavy chain, mitogen activated extra-cellular signal regulated kinase-1. Induces dedifferentiation of lineage-committed mouse myoblasts to multipotent progenitors with osteogenic and adipogenic potential. Induces dedifferentiation of primary mouse and human dermal fibroblasts to myogenic-competent cells. Induces dedifferentiation of annulus fibrosus cells to multipotent mesenchymal progenitors that have the potential to develop along chondrogenic, osteogenic, or adipogenic lineages. Inhibits cell proliferation and induces polyploidy in the PC-3, HeLa, CWR22Rv1, and DU-145 cancer cell lines. Induces differentiation in the human embryonal carcinoma cell line NT2, and in the human promyelocytic leukemia cell line HL60. Blocks proliferation, causes failure of cytokinesis, and induces polyploidy in multiple cancer cell lines.