S3I-201, STAT3 inhibitor (RMML-00120672)
Cat. No.: RMML-00120672
Category: Inhibitors & Activators
INQUIRY
5 mg
25 mg
Novel, selective STAT3 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 97% |
| Key Features | Novel, selective STAT3 inhibitor; CAS Number: 501919-59-1; Purity: > 97%; Soluble in DMSO to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | STAT3 |
|---|---|
| Biological Description | Novel, selective STAT3 inhibitor (IC50 values are 86 (STAT3.STAT3), 160 (STAT1.STAT3), 166 (STAT1.STAT1) and >300 μM (STAT5.STAT5) for DNA-binding activity). Inhibits complex formation, STAT3 tyrosine phosphorylation and DNA-binding. Inhibits growth and induces apoptosis. Antitumor activity in vivo. |
| Alternative Names | NSC 74859 |
| CAS Number | 501919-59-1 |
| Chemical Name | 2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
| Molecular Formula | C16H15NO7S |
| Molecular Weight | 365.36 Da |
| PubChem Identifier | 252682 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO to 25 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
