SAG (Smo agonist), Smoothened agonist (RMML-00120185)
Cat. No.: RMML-00120185
Category: Inhibitors & Activators
INQUIRY
5 mg
1 mg
Cell-permeable, selective, potent Smoothened agonist
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Cell-permeable, selective, potent Smoothened agonist; CAS Number: 912545-86-9; Purity: > 98%; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | Smoothened |
|---|---|
| Biological Description | Cell-permeable, selective, potent Smoothened agonist (EC50 = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine action. Active in vitro and in vivo. |
| CAS Number | 912545-86-9 |
| Chemical Name | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide |
| SMILES | CN[C@H]1CC[C@@H](CC1)N(Cc2ccc(cc2)c3ccncc3)C(=O)c5sc4ccccc4c5Cl |
| Molecular Formula | C28H28ClN3OS |
| Molecular Weight | 490.06 Da |
| PubChem Identifier | 5284330 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
