A-485 (RMML-00120062)
Cat. No.: RMML-00120062
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
A potent HAT inhibitor
Product Features
Purity | ≥ 98% |
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Key Features | A potent HAT inhibitor; CAS Number: 1889279-16-6; Purity: ≥ 98%; >40 mg/mL in DMSO; >40 mg/mL in Ethanol; Form / State: Solid |
Compound Information
Biological Description | A potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). A-485 displays > 1000-fold selectivity over closely related HATs. It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkin's, and acute myeloid leukemia cell lines. |
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Alternative Names | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, CHEMBL4282264 |
CAS Number | 1889279-16-6 |
Chemical Name | N-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide |
SMILES | C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O |
Molecular Formula | C25H24F4N4O5 |
Molecular Weight | 536.48 Da |
PubChem Identifier | 118958122 |
Storage & Shipping
Handling | Refer to SDS for further information. |
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Solubility | >40 mg/mL in DMSO>40 mg/mL in Ethanol |
Storage & Shipping | Shipped at 4°C. Store at -20°C. It is important to note that this product is reported to be light sensitive. Store in the dark. |
For research use only. Not for clinical use.