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A-485 (RMML-00120062)

Cat. No.: RMML-00120062

Category: Inhibitors & Activators

INQUIRY 1 mg 5 mg
A potent HAT inhibitor

Product Features

Purity ≥ 98%
Key Features A potent HAT inhibitor; CAS Number: 1889279-16-6; Purity: ≥ 98%; >40 mg/mL in DMSO; >40 mg/mL in Ethanol; Form / State: Solid

Compound Information

Biological Description A potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). A-485 displays > 1000-fold selectivity over closely related HATs. It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkin's, and acute myeloid leukemia cell lines.
Alternative Names (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, CHEMBL4282264
CAS Number 1889279-16-6
Chemical Name N-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
SMILES C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O
Molecular Formula C25H24F4N4O5
Molecular Weight 536.48 Da
PubChem Identifier 118958122

Storage & Shipping

Handling Refer to SDS for further information.
Solubility >40 mg/mL in DMSO>40 mg/mL in Ethanol
Storage & Shipping Shipped at 4°C. Store at -20°C. It is important to note that this product is reported to be light sensitive. Store in the dark.

For research use only. Not for clinical use.