A769662

A769662 is a cell-permeable, direct activator of AMP-activated protein kinase. A 4. 1-fold stimulation of AMPK is observed, via an allosteric mechanism, which potentially inhibits dephosphorylation on Thr172. A769662 specifically activates β1 subunit–containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. Activation of AMPK can inhibit the mTORC1 signaling pathway. A769662 is also an inhibitor of Na(+)-K(+)-ATPase. Inhibits reprogramming of mouse fibroblasts to induced pluripotent stem cells. Inhibits proliferation of mesenchymal stem cells. Delays tumor onset in PTEN-deficient mice. Inhibits fatty acid synthesis in primary rat hepatocytes and lowers blood glucose in Sprague Dawley rats.