BI-D1870, RSK Inhibitor (RMML-00120178)
Cat. No.: RMML-00120178
Category: Inhibitors & Activators
INQUIRY
5 mg
25 mg
Cell-permeable, ATP-competitive RSK inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Cell-permeable, ATP-competitive RSK inhibitor; CAS Number: 501437-28-1; Purity: > 98%; Soluble in DMSO to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | RSK |
|---|---|
| Biological Description | Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC50 = 31 nM; RSK2 IC50 = 24 nM; RSK3 IC50 = 18 nM; RSK4 IC50 = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1/CIP1 pathways. |
| CAS Number | 501437-28-1 |
| Chemical Name | 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone |
| SMILES | CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C |
| Molecular Formula | C19H23F2N5O2 |
| Molecular Weight | 391.40 Da |
| PubChem Identifier | 25023738 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 25 mM |
| Storage & Shipping | Shipped at room temperature. Store at -20°C. |
For research use only. Not for clinical use.
