AAL 993, VEGFR inhibitor (RMML-00120795)
Cat. No.: RMML-00120795
Category: Inhibitors & Activators
INQUIRY
25 mg
5 mg
Potent, selective and cell-permeable VEGFR inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent, selective and cell-permeable VEGFR inhibitor; CAS Number: 269390-77-4; Purity: > 98%; Soluble in ethanol to 25 mM and in DMSO to 50 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | VEGFR |
|---|---|
| Biological Description | Potent, selective and cell-permeable VEGFR inhibitor (IC50 values are 130, 23 and 18 nM for VEGFR1, 2, and 3 respectively). Inhibits VEGF-induced angiogenesis in vivo. Suppresses hypoxia-induced HIF-1α expression without affecting Akt phosphorylation in vitro. |
| CAS Number | 269390-77-4 |
| Chemical Name | 2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3 |
| Molecular Formula | C20H16N3OF3 |
| Molecular Weight | 371.40 Da |
| PubChem Identifier | 6398883 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in ethanol to 25 mM and in DMSO to 50 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
