Anti-14-3-3 Antibody (RMAB-0250017)
Cat. No.: RMAB-0250017
Category: Primary Antibodies
INQUIRY
100 μL
1 mL
Rabbit monoclonal to 14-3-3
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR6379 |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to 14-3-3; Suitable for: WB; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | YWHAB |
|---|---|
| Target Name | 14-3-3 protein beta/alpha |
| UniProt ID | P31946 |
| Cellular Localization | Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. |
| Post-translational Modifications | The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated on Ser-6 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Isoform Short contains a N-acetylmethionine at position 1. |
| Sequence Similarities | Belongs to the 14-3-3 family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
