Anti-BMP4 Antibody (RMAB-0250107)
Cat. No.: RMAB-0250107
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to BMP4
Product Features
Isotype | IgG |
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Clonality | Monoclonal |
Host Species | Rabbit |
Clone Number | EPR6211 |
Form | Liquid |
Purity | Protein A purified |
Species Reactivity | Human |
Immunogen | Synthetic peptide corresponding to Human BMP4 aa 35 to the C-terminus. |
Applications | Flow Cyt (Intra), WB, IP, IHC-P, ICC/IF |
Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to BMP4; Suitable for: Flow Cyt (Intra), WB, IP, IHC-P, ICC/IF; Reacts with: Human |
Target Information
Target Symbol | BMP4 |
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Target Name | Bone morphogenetic protein 4 |
UniProt ID | P12644 |
Cellular Localization | Secreted > extracellular space > extracellular matrix. |
Function | Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. |
Involvement in Disease | Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6); also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. |
Sequence Similarities | Belongs to the TGF-beta family. |
Storage & Shipping
Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA |
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Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.