Anti-Cardiac Troponin T Antibody (RMAB-0250142)
Cat. No.: RMAB-0250142
Category: Primary Antibodies
INQUIRY
100 μL
10 µL
Rabbit monoclonal to Cardiac Troponin T
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR26703-8 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | mIHC, WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Cardiac Troponin T; Suitable for: mIHC, WB, IHC-P; Reacts with: Human |
Target Information
| Target Symbol | TNNT2 |
|---|---|
| Target Name | Troponin T, cardiac muscle |
| UniProt ID | P45379 |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Involvement in Disease | Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3). Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. |
| Sequence Similarities | Belongs to the troponin T family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
