Anti-CD276 Antibody (RMAB-0250270)
Cat. No.: RMAB-0250270
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD276
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPNCIR122 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Human, Recombinant fragment |
| Immunogen | Recombinant full length protein corresponding to Human CD276. Alternate injections with Human recombinant protein and Human CD276 over-expressing CHO cells. |
| Applications | IHC-Fr, WB, IP, Flow Cyt, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD276; Suitable for: IHC-Fr, WB, IP, Flow Cyt, ICC/IF; Knockout validated; Reacts with: Mouse, Human, Recombinant fragment |
Target Information
| Target Symbol | CD276 |
|---|---|
| Target Name | CD276 antigen |
| UniProt ID | Q5ZPR3 |
| Cellular Localization | Membrane. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Sequence Similarities | Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
