Anti-CD45 Antibody (RMAB-0250378)
Cat. No.: RMAB-0250378
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to CD45
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20033 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide. |
| Applications | IHC-P, WB, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD45; Suitable for: IHC-P, WB, IP; Reacts with: Mouse, Human |
Target Information
| Target Symbol | PTPRC |
|---|---|
| Target Name | Receptor-type tyrosine-protein phosphatase C |
| UniProt ID | P08575 |
| Cellular Localization | Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. |
| Involvement in Disease | Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID). A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS). MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain. |
| Post-translational Modifications | Heavily N- and O-glycosylated. |
| Domain | The first PTPase domain interacts with SKAP1. |
| Sequence Similarities | Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
