Anti-ER81/ETV1 Antibody (RMAB-0250548)
Cat. No.: RMAB-0250548
Category: Primary Antibodies
INQUIRY
100 μL
10 µL
Rabbit monoclonal to ER81/ETV1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR28393-132 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | ICC/IF, WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to ER81/ETV1; Suitable for: ICC/IF, WB, IHC-P; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | ETV1 |
|---|---|
| Target Name | ETS translocation variant 1 |
| UniProt ID | P50549 |
| Cellular Localization | Nucleus. |
| Function | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. |
| Involvement in Disease | Defects in ETV1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7; 22)(p22; q12) with EWSR1. |
| Post-translational Modifications | Sumoylated. |
| Sequence Similarities | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
