Anti-HMGA2 Antibody (RMAB-0250714)
Cat. No.: RMAB-0250714
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to HMGA2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR23215-46 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | Flow Cyt (Intra), WB, ICC/IF, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to HMGA2; Suitable for: Flow Cyt (Intra), WB, ICC/IF, IP; Reacts with: Human |
Target Information
| Target Symbol | HMGA2 |
|---|---|
| Target Name | High mobility group protein HMGI-C |
| UniProt ID | P52926 |
| Cellular Localization | Nucleus. |
| Developmental Stage | Expressed predominantly during embryogenesis. |
| Function | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. |
| Involvement in Disease | A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3; 12)(q27-q28; q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3; 12)(q27-q28; q14-q15) with LPP is detected in pulmonary chondroid hamartomas.A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3; 12)(q28; q14) with LPP is also shown in one parosteal lipoma.A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12; 14)(q15; q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma. |
| Post-translational Modifications | Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. |
| Sequence Similarities | Belongs to the HMGA family. Contains 3 A.T hook DNA-binding domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
