Anti-Human BMP-7 Monoclonal Antibody (RMAB-0251809)
Cat. No.: RMAB-0251809
Category: Primary Antibodies
INQUIRY
500 μg
Customer Size
Product Features
| Clonality | Monoclonal |
|---|---|
| Host Species | Mouse |
| Immunogen | CHO cell derived Recombinant Human BMP-7 |
Target Information
| Target Symbol | BMP7 |
|---|---|
| Target Name | Bone morphogenetic protein 7 |
| UniProt ID | P18075 |
| Cellular Localization | Secreted. |
| Function | Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:3128997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:3128997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:2792361). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:39759). |
| Post-translational Modifications | Several N-termini starting at positions 293, 3, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. |
| Sequence Similarities | Belongs to the TGF-beta family. |
For research use only. Not for clinical use.
