Anti-Human GDNF Polyclonal Antibody (RMAB-0251603)
Cat. No.: RMAB-0251603
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Recombinant Human GDNF |
Target Information
| Target Symbol | GDNF |
|---|---|
| Target Name | Glial cell line-derived neurotrophic factor |
| UniProt ID | P39905 |
| Cellular Localization | Secreted. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. |
| Involvement in Disease | Hirschsprung disease 3 (HSCR3): A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. Disease susceptibility is associated with variants affecting the gene represented in this entry. Pheochromocytoma (PCC): A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. The gene represented in this entry may act as a disease modifier. |
| Sequence Similarities | Belongs to the TGF-beta family. GDNF subfamily. |
For research use only. Not for clinical use.
