Anti-Occludin Antibody - Neural Stem Cell Marker (RMAB-0250928)
Cat. No.: RMAB-0250928
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Rabbit polyclonal to Occludin - Neural Stem Cell Marker
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Recombinant full length protein corresponding to Human Occludin aa 1 to the C-terminus. |
| Applications | WB, IHC-P |
| Key Features | Rabbit polyclonal to Occludin - Neural Stem Cell Marker; Suitable for: WB, IHC-P; Reacts with: Mouse, Human; Isotype: IgG |
Target Information
| Target Symbol | OCLN |
|---|---|
| Target Name | Occludin |
| UniProt ID | Q16625 |
| Cellular Localization | Membrane. Cell junction > tight junction. |
| Function | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. |
| Involvement in Disease | Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG); also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay. |
| Post-translational Modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-42 reduces its ability to interact with TJP1. |
| Domain | The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction. |
| Sequence Similarities | Belongs to the ELL/occludin family. Contains 1 MARVEL domain. |
Storage & Shipping
| Storage Buffer | pH: 7.4; Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
