Anti-SOX2 Antibody (RMAB-0251090)
Cat. No.: RMAB-0251090
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to SOX2
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 9-9-3 |
| Form | Liquid |
| Purity | IgG fraction |
| Species Reactivity | Mouse, Human, Apteronotus leptorhynchus |
| Immunogen | Synthetic peptide corresponding to Human SOX2 aa 3 to the C-terminus |
| Applications | ICC/IF, WB, Flow Cyt (Intra) |
| Key Features | Mouse monoclonal to SOX2; Suitable for: ICC/IF, WB, Flow Cyt (Intra); Reacts with: Mouse, Human, Apteronotus leptorhynchus; Isotype: IgG1 |
Target Information
| Target Symbol | SOX2 |
|---|---|
| Target Name | Transcription factor SOX-2 |
| UniProt ID | P48431 |
| Cellular Localization | Nucleus. |
| Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Involvement in Disease | Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. |
| Post-translational Modifications | Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
| Sequence Similarities | Contains 1 HMG box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituents: 6.97% L-Arginine, PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
