Anti-TBX21 Rabbit Monoclonal Antibody (RMAB-0251511)
Cat. No.: RMAB-0251511
Category: Primary Antibodies
Research Area: Immunology, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-TBX21 Rabbit Monoclonal Antibody. Tested in Flow Cytometry, IHC applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human T-bet/ Tbx21 aa 485-535 (C terminal). The exact sequence is proprietary. |
| Applications | WB, IHC, IF, ICC |
Target Information
| Target Symbol | TBX21 |
|---|---|
| Target Name | T-box transcription factor TBX21 |
| UniProt ID | Q9UL17 |
| Function | Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. |
| Involvement in Disease | Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI). A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. |
| Sequence Similarities | Contains 1 T-box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
