Biotinylated Anti-Human IL-13 Polyclonal Antibody (RMAB-0251703)
Cat. No.: RMAB-0251703
Category: Primary Antibodies
INQUIRY
25 μg
50 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Recombinant Human IL-13 |
Target Information
| Target Symbol | IL13 |
|---|---|
| Target Name | Interleukin-13 |
| UniProt ID | P35225 |
| Cellular Localization | Secreted. |
| Function | Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:896327, PubMed:897324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:896327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:79368, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL1, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:913879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). |
| Involvement in Disease | Allergic rhinitis (ALRH): A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Disease susceptibility is associated with variants affecting the gene represented in this entry. |
| Sequence Similarities | Belongs to the IL-4/IL-13 family. |
For research use only. Not for clinical use.
