Clioquinol, Metal chelator and ionophore (RMML-00120629)
Cat. No.: RMML-00120629
Category: Inhibitors & Activators
INQUIRY
1 g
100 mg
Metal chelator and ionophore
Product Features
| Source | Synthetic |
|---|---|
| Key Features | Metal chelator and ionophore; CAS Number: 130-26-7; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Biological Description | Metal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease). Effects on Alzheimer's disease attributed to copper and zinc chelation or increased level of a metalloprotease. Other actions reported including iron chelation, inhibition of Huntington expression from its mRNA, proteasome inhibition when complexed with copper, and stimulation of tumor necrosis factor-α secretion. Also inhibitor of CLK-1/MCLK1 (an aging-associated protein). |
|---|---|
| CAS Number | 130-26-7 |
| Chemical Name | 5-Chloro-8-hydroxy-7-iodoquinoline |
| SMILES | Oc1c(I)cc(Cl)c2cccnc12 |
| Molecular Formula | C9H5ClINO |
| Molecular Weight | 305.50 Da |
| PubChem Identifier | 2788 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Store at room temperature. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
