Dorsomorphin (Compound C), AMP-kinase inhibitor (RMML-00120797)
Cat. No.: RMML-00120797
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.; CAS Number: 866405-64-3; Purity: > 99%; Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating); Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | AMP-kinase |
|---|---|
| Biological Description | Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821) |
| Alternative Names | Compound C |
| CAS Number | 866405-64-3 |
| Chemical Name | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine |
| SMILES | c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5 |
| Molecular Formula | C24H25N5O |
| Molecular Weight | 399.49 Da |
| PubChem Identifier | 11524144 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Please note that sonication in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating) |
| Storage & Shipping | Store at 4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
