Human FAS Ligand Antibody Pair - BSA and Azide free (RMAB-0252224)
Cat. No.: RMAB-0252224
Category: Antibody Pair
INQUIRY
10 x 96 tests
Human FAS Ligand Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to quantify human CNTFR in sandwich ELISAs and many other pair-based applications._x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Human |
| Range | 15.6 pg/mL - 1000 pg/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Human |
Target Information
| Target Symbol | FASLG |
|---|---|
| Target Name | Tumor necrosis factor ligand superfamily member 6 |
| UniProt ID | P48023 |
| Cellular Localization | Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface. |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. |
| Involvement in Disease | Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B); also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. |
| Post-translational Modifications | N-glycosylated. The soluble form derives from the membrane form by proteolytic processing. |
| Sequence Similarities | Belongs to the tumor necrosis factor family. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
|---|
For research use only. Not for clinical use.
