Human MEIS1 Protein (RMPP-00230363)
Cat. No.: RMPP-00230363
Category: Native Protein
Research Area: Immunology
INQUIRY
10 μg
Customer Size
Product Features
| Source | Native |
|---|---|
| Purity | > 90% SDS-PAGE. |
| Nature | Native |
| Animal Free | No |
| Form | Liquid |
| Applications | Functional Studies; SDS-PAGE |
| Key Features | Expression system: Native; Purity: > 90% SDS-PAGE; Active: Yes; Suitable for: Functional Studies, SDS-PAGE |
Protein Information
| UniProt ID | P15144 |
|---|---|
| Molecular Weight | 110 kDa |
| Sequence | MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTT PSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGL YVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDI DKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYME GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP KDLTALSN MLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGV LIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPD FNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNL VTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDA LASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQ GLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMG FPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQ DYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQR DHSAIPVINRAQ IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWE AALSSLSYFKLMFDRSEVYGPMKN YLKKQVTPLFIHFRNNTNNWREIP ENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM ENPNNNPIHPNL RSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFND YGGGSFSFSN LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALE QALEKTKANIKWVKENKEVVLQ WFTENSK |
| Sequence Similarities | Belongs to the peptidase M1 family. |
| Protein Length | Full length protein |
| Cellular Localization | Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected. |
| Tissue Specificity | Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients. |
| Domain | Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies). |
| Function | Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. |
| Post-translational Modifications | Sulfated.N- and O-glycosylated.May undergo proteolysis and give rise to a soluble form. |
Storage & Shipping
| Shipping and Storage | Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. pH: 7.40Constituents: 0.01% Calcium chloride, 0.32% Tris HCl, 2.92% Sodium chloride This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
