Human Recombinant IL-7

Interleukin 7. IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals thro μgh the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Altho μgh a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).